Hurricane the storm is predicted to strengthen into a infrequent Category 5 hurricane as it turns towards the Caribbean island, delivering deadly rapid inundation and mudslides.
The hurricane, which had wind speeds of up to 120 mph as of 06:00 GMT, is currently turning north-west in the Caribbean Sea and is anticipated to make landfall by Tuesday, as reported by weather experts.
Warnings of power cuts and disruption to utilities have been issued as the hurricane brings up to 76cm of precipitation and storm surges as high as 4m above ground. "Find safe refuge immediately," locals have been told.
This hurricane is the 13th named storm in the current Atlantic storm period, which usually concludes in November.
A category five storm is the most powerful category, with sustained winds of at least 157mph.
Although the hurricane is set to weaken to a Category 4 storm before reaching the island, authorities said there was "very little practical difference in the general consequences" upon making contact with land, and that the storm will be "equally strong" when it strikes the island.
With tropical storm-strength gusts and precipitation already expected ahead of it passes over Jamaica's central region - including potentially the city of Kingston - warnings indicate that "safety measures need to be finalized quickly".
"Several days of damaging winds and intense precipitation are underway and will cause catastrophic and life-threatening flash flooding and many rock slides," counseled weather authorities.
The nation's leader Andrew Holness stated: "I understand that there are numerous residents who are anxious, who are extremely apprehensive, and appropriately: concern is justified.
"However the best way to handle anxiety and any apprehension and concern is to stay ready."
Residents are being advised to fortify their houses with sandbags and timber panels, and to gather essentials.
Warnings are also ongoing for parts of Haiti including the primary urban center, the adjacent nation and eastern Cuba, where Melissa is expected to bring similar effects by the middle of next week.
Rock slides currently triggered by the storm have resulted in two fatalities in Haiti, according to emergency services.
Melissa is forecast to pass over Cuba by midweek before traveling via the Greater Antilles and entering the Atlantic.
By the point it reaches the Caribbean nation, it is anticipated to have weakened to a Category 3 cyclone.
While it is difficult to connect particular meteorological occurrences to environmental shifts, researchers say it is causing weather phenomena more prevalent and more severe.
Increased sea temperatures generate additional humidity in the air, contributing to the formation of hurricanes.
Ahead of the beginning of this year's Atlantic storm period, meteorological authorities projected higher-than-average occurrence, mentioning heated marine conditions and potential more intense weather patterns around West Africa - where Atlantic storms frequently develop.
Maya Sterling is a film critic with over a decade of experience, passionate about uncovering hidden gems in cinema.